Author(s)

Biswadip Ghosh¹, Debasish Baidya², Pampa Halder³, Shamash Mandal⁴

¹Department of Rheumatology, IPGME&R and SSKM Hospital, Kolkata, India.
²Marwari Hospital and Research Centre, Guwahati, India.
³Department of Ophthalmology, RG Kar Medical College, Kolkata, India.
⁴Department of Medicine, BS Medical College, Bankura, India.

Rheumatoid Arthritis is characterized by increased cardiovascular morbidity and mortality that cannot be fully explained by the presence of classical cardiovascular disease (CVD) risk factors suggesting that novel risk factors may play a role. Evidence accumulated over the past decade points that uric acid (UA) may be one such novel CVD risk factor in rheumatoid arthritis, and therefore one may hypothesize that UA may contribute to the increased CVD burden in RA. The current study attempted to correlate the levels of clinical disease activity index (CDAI), high sensitivity C reactive protein (hs-CRP) and uric acid in DMARD naive non-diabetic, non-hypertensive, euthyroid patients with normal lipid profile suffering from early and established Rheumatoid Arthritis before and after 3 months of DMARD therapy. It showed a positive and significant correlation among uric acid levels and CDAI and hs-CRP levels at diagnosis. There was significant reduction in the levels of CDAI, hs-CRP and UA after 3 months of DMARD therapy with significant correlation among the changes in the 3 parameters and the change in Uric Acid also correlated with the levels of CDAI and hs-CRP at diagnosis. We propose to measure uric acid both as acute phase reactant and marker for cardiovascular morbidity in patients suffering from Rheumatoid Arthritis.

Uric Acid, Rheumatoid Arthritis, CDAI, CRP

Ghosh, B. , Baidya, D. , Halder, P. and Mandal, S. (2016) Correlation of Serum Uric Acid with Disease Activity and C-Reactive Protein in Patients Suffering from Rheumatoid Arthritis. Open Journal of Rheumatology and Autoimmune Diseases, 6, 79-84. doi: 10.4236/ojra.2016.63013.