Author(s)

Kenji D. Furukawa, Naoto Yamaaki, Aya Fujimoto, Kiminori Ohyama, Hiroaki Muramoto

Department of Internal Medicine, Japan Community Health care Organization (JCHO) Kanazawa Hospital, Kanazawa, Japan.

We implemented a 3-3-1 algorithm in order to provide safe and simple self-titration in patients who newly initiated BOT as well as who were already on BOT and evaluated its utility in clinical setting. A total of 46 patients, 21 patients in the newly-initiated group and 25 patients in the existing BOT group performed dose adjustment using 3-3-1 algorithm. HbA1c was significantly improved 4 weeks after the initiation from 8.5% ± 1.2% at baseline to 7.3% ± 0.7% at the final evaluation (p < 0.01, vs. Baseline). The average daily insulin units increased throughout the study period from 10.1 ± 6.7 at baseline to 14.6 ± 8.9 units at the final evaluation. Weight didn’t significantly change throughout the study (p = 0.12). The incidents of hypoglycemia were 0.8/month during the insulin dose self-adjustment period and 0.4/month during the follow-up period. The 3-3-1 algorithm using insulin glargine provided a safe and simple dose adjustment and demonstrated its utility in patients who were newly introduced to insulin treatment as well as who were already on BOT.

Glargine, Self-Titration, BOT, T2DM, Insulin, 3-3-1 Algorithm

Furukawa, K. , Yamaaki, N. , Fujimoto, A. , Ohyama, K. and Muramoto, H. (2016) Simple Insulin Dose Adjustment Using 3-3-1 Algorithm in Japanese Patients with Type 2 Diabetes: Start Kanazawa Study (Self-Titration Aggressive Algorithm with Glargine Trial). Journal of Diabetes Mellitus, 6, 197-203. doi: 10.4236/jdm.2016.63022.