Author(s)

Alberto Olaya-Vargas^1*, Martín Pérez-García², Nideshda Ramírez-Uribe², M. Angeles Del Campo-Martinez², Gerardo Lopez-Hernández², Montserrat Hernández-García³, Jorge Amador-Zarco⁴, Guadalupe Garcia-Vega⁴, Yadira Melchor-Vidal⁵, Marta Zapata-Tarres⁶, Rocío Cárdenas-Cardos⁶, Roberto Rivera-Luna⁷

¹Hematopoietic Stem Cell Transplant Unit (HSCTU) from Pediatric National Institute (INP), Mexico City, Mexico.
²Pediatric Bone Marrow Transplant Program at the HSCTU INP, Mexico City, Mexico.
³Pediatric Bone Marrow Transplant Program at the HSCTU-HITO Hospital, Mexico City, Mexico.
⁴Radiotherapy Department, INP, Mexico City, Mexico.
⁵Pediatric Bone Marrow Transplant Program at the HSCTU-ABC Medical Center, Mexico City, Mexico.
⁶Department of Pediatric Oncology from the INP, Mexico City, Mexico.
⁷Division of Pediatric Hem/Oncology from the INP, Mexico City, Mexico.

Total body irradiation (TBI) is conditioning regimen in children with acute lymphoblastic leukemia (ALL) with a very high risk of relapse or in those who have not achieved remission and have relapsed and subsequently received allogenic hematopoietic stem cell transplantation (HSCT). A retrospective evaluation of 33 ALL patients in full remission with an indication of HSCT was performed to evaluate overall survival (OS) and event-free survival (EFS). The inclusion criteria included a myeloablative conditioning regimen of TBI at a dose of 600 cGy. The observed OS at 5 years was 50%, and the EFS of 32% we observed difference in the EFS stem cell origin; the peripheral blood (PB) 60%, and the umbilical cord blood (UC) accounted for 40%. Overall, 45% had a documented chimerism. The OS at 5 years from patients with chimeras was 75%, while those without chimeras had an OS at 5 years of 25%. The mortality in the first 100 days was 24%. A total of 24.2% of children presented with acute graft versus-host disease (GVHD), while 33% had chronic GVHD. Currently, there is no general agreement among all international centers regarding the optimum TBI dose. Our study reports an acceptable range of adverse events with a relatively low dose of 600 cGy.

Total Body Irradiation, Stem Cell Transplantation

Olaya-Vargas, A. , Pérez-García, M. , Ramírez-Uribe, N. , Campo-Martinez, M. , Lopez-Hernández, G. , Hernández-García, M. , Amador-Zarco, J. , Garcia-Vega, G. , Melchor-Vidal, Y. , Zapata-Tarres, M. , Cárdenas-Cardos, R. and Rivera-Luna, R. (2016) Low Dose Total Body Irradiation (600 cGy) as a Conditioning Regimen in Allogenic Hematopoietic Stem Cell Transplant in Children with Acute Lymphoblastic Leukemia. Journal of Cancer Therapy, 7, 586-592. doi: 10.4236/jct.2016.78061.