Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety - Open Access Library Journal

OALibJ > Vol.3 No.7, July 2016

Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety ()

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DOI: 10.4236/oalib.1102876 1,630 Downloads 3,299 Views Citations

Author(s)

Samir B. Salib, Omneya M. Khalil, Mona M. Kamel, Yara El-Dash

Affiliation(s)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

ABSTRACT

The present study focused on synthesizing a series of novel derivatives of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl) acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The structure of the synthesized compounds has been elucidated on the basis of elemental analyses and spectroscopic methods (IR, ¹H-NMR, ¹³C-NMR and MS). The in vitro cytotoxic activity of the synthesized derivatives was evaluated against two human cell lines: prostate cancer (PC-3) and colon cancer (HCT-116).

KEYWORDS

Synthesis, Thieno[2, 3-d]Pyrimidine, Thiosemicarbazides, Anticancer Agents

Share and Cite:

Salib, S. , Khalil, O. , Kamel, M. and El-Dash, Y. (2016) Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety. Open Access Library Journal, 3, 1-7. doi: 10.4236/oalib.1102876.

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