Andrographis peniculata: Capabilities against Free Radicals, Lipid Peroxidation, Hepatotoxicity, and Nephrotoxicity - Open Access Library Journal

OALibJ > Vol.3 No.7, July 2016

Andrographis peniculata: Capabilities against Free Radicals, Lipid Peroxidation, Hepatotoxicity, and Nephrotoxicity ()

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DOI: 10.4236/oalib.1102541 894 Downloads 1,745 Views Citations

Author(s)

Godwin O. Adejo^1*, Joseph M. Gnimintakpa¹, Olufunsho D. Olowoniyi², Paulinus Obinna Matthew³

Affiliation(s)

¹Department of Biochemistry & Molecular Biology, Federal University, Dutsin-Ma, Nigeria.
²Department of Biochemistry, Kaduna State University, Kaduna, Nigeria.
³Department of Biochemistry, Faculty of Science and Technology, Bingham University, Auta-Balefi, Nigeria.

ABSTRACT

This work was about Andrographis peniculata (Burm. F). Ab initio, the LD₅₀ test showed non-toxicity at the highest administered dose of 5000 mg/kg in rats. Male albino Wistar rats were treated with daily single doses of ethanol extracts (100/200/500 mg/kg) of Andrographis peniculata (A.p.) for 14 days with intermittent administration, i.p., of CCl₄ every four days. Liver and kidney TBARS concentrations showed lower values with increased doses of extract administration. In both cases, “CCl₄ A.p. 500 mg/kg” values compared to “CCl₄ Silymarin” group, while “CCl₄ A.p. 100 mg/kg” showed no significant difference from “CCl₄ only” group. The “NC” (normal control) however, presented the least concentration of 66.17 ± 2.74 and 38.04 ± 4.34 nmol/mg protein, respectively. Total and Indirect bilirubin concentrations indicated decreased values with increasing doses, such that respectively, the lowest values of 1.18 ± 0.47 and 0.98 ± 0.31 mg/dl in the “CCl₄ A.p. 500 mg/kg” group were observed. There was no significant difference among all the various groups except the “NC” which showed the least value. Urea and creatinine levels were significantly higher (p ≤ 0.05) in the “CCl₄ only” group than all others. Liver function parameters, viz., AST and ALT indicated significantly higher values in the “CCl₄ only” group, compared to all others (p ≤ 0.05). Values obtained for “CCl₄ A.p. (500 mg/kg)” were comparable to the “NC” and “CCl₄ Silymarin” groups.

KEYWORDS

Andrographis peniculata, Peroxidation, Hepatotoxicity, Nephrotoxicity

Share and Cite:

Adejo, G. , Gnimintakpa, J. , Olowoniyi, O. and Matthew, P. (2016) Andrographis peniculata: Capabilities against Free Radicals, Lipid Peroxidation, Hepatotoxicity, and Nephrotoxicity. Open Access Library Journal, 3, 1-9. doi: 10.4236/oalib.1102541.

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