The Role of Trp-p8 Combined with PSADTZ Determinated in the Early Diagnosis of Prostate Cancer - Open Access Library Journal

OALibJ > Vol.3 No.6, June 2016

The Role of Trp-p8 Combined with PSADTZ Determinated in the Early Diagnosis of Prostate Cancer ()

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DOI: 10.4236/oalib.1102626 630 Downloads 1,614 Views

Author(s)

Xinsheng Zhang^1*, Ying Zhang², Panxing Wu¹, Shuijiao Liu¹, Jianyu Zhou³

Affiliation(s)

¹Department of Urology, Taizhou Central Hospital, Taizhou, China.
²Department of Blood Transfusion, Taizhou Central Hospital, Taizhou, China.
³Department of Ultrasound Imaging, Taizhou Central Hospital, Taizhou, China.

ABSTRACT

Objective: To study the expression of Transient receptor potential p8 (Trp-p8) in prostate tissues of prostate-specific antigen (PSA) in “grey district” with different PSA density of transition zone (PSADTZ) interval and explore the role of Trp-p8 and PSADTZ determinated in the early diagnosis on prostate cancer. Methods: Immunohistochemical and RT-PCR were applied to determinate Trp-p8 in the prostate cancer and benign prostatic hyperplasia group with different PSADTZ interval, which were both 30 specimens. The difference of expression level was judged and analyzed. Results: The expression of Trp-p8 was weak or negative in the benign prostatic hyperplasia group, while it appeared to be far more abundant in prostate cancer group and was higher in PSADTZ group, the difference was of statistical significance. Conclusions: The expression of Trp-p8 in prostate tissues of PSA in grey district was different. The expression in prostate cancer was higher than that in benign prostatic hyperplasia group.

KEYWORDS

Trp-p8, Prostate Cancer, Benign Prostatic Hyperplasia, Immunohistochemical, PSADTZ, RT-PCR

Share and Cite:

Zhang, X. , Zhang, Y. , Wu, P. , Liu, S. and Zhou, J. (2016) The Role of Trp-p8 Combined with PSADTZ Determinated in the Early Diagnosis of Prostate Cancer. Open Access Library Journal, 3, 1-7. doi: 10.4236/oalib.1102626.

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