Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group - Open Access Library Journal

OALibJ > Vol.3 No.5, May 2016

Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group ()

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DOI: 10.4236/oalib.1102635 757 Downloads 1,967 Views Citations

Author(s)

Rihab Sendesni¹, Dhaker Lahidheb², Manel Ayoub¹, Nedra Grira¹, Dhekra Lafi¹, Nejla Stambouli¹, Mabrouka El Oudi¹, Ezzedine Ghazouani³, Habib Haouala², Zied Aouni¹, Chakib Mazigh¹

Affiliation(s)

¹Biochemistry Department, Research Unit UR12DN02, Military Hospital of Tunis, Tunis, Tunisia.
²Cardiology Department, Research Unit UR12DN02, Military Hospital of Tunis, Tunis, Tunisia.
³Immunology Department, Military Hospital of Tunis, Tunis, Tunisia.

ABSTRACT

Aims: To evaluate the relationship between inflammatory biomarkers and lipid parameters in a Tunisian coronary artery disease group. Material and Methods: In the study, we have included 122 subjects with acute coronary syndrome (ACS) confirmed by coronary angiography, selected among patients admitted to the cardiology department and 162 subjects free of any cardiovascular disease, recruited from medical and paramedical volunteers. Lipid parameters, high sensitivity CRP (hsCRP) and proinflammatory cytokines (IL6, IL8 and TNFα) were determined for all patients and controls. Results: A highly significant difference (P < 10^﹣³) was noted between the mean of the hsCRP in coronary patients (14.65 ± 9.81 mg/L) compared to controls (1.63 ± 1.75 mg/L). We note also a significant difference between the means of IL6 in the diseased population (11.56 ± 8.23 pg/mL) compared to controls (2.5 ± 0.84 pg/mL) with a value of P < 10^﹣³. The hsCRP values are inversely correlated with the HDLc values. No association was found between IL 8 and the various lipid parameters. Patients having high IL6 values had higher levels of CT and CT/HDLc ratio. This correlation is statistically significant. Regarding TNFα, there is a positive and significant correlation with CT and LDLc. Conclusion: Significant correlation was found between inflammatory markers and lipids profile. This may explain the role of inflammation in the development of cardiovascular disease.

KEYWORDS

Inflammation, Lipids, Acute Coronary Syndrome

Share and Cite:

Sendesni, R. , Lahidheb, D. , Ayoub, M. , Grira, N. , Lafi, D. , Stambouli, N. , Oudi, M. , Ghazouani, E. , Haouala, H. , Aouni, Z. and Mazigh, C. (2016) Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group. Open Access Library Journal, 3, 1-9. doi: 10.4236/oalib.1102635.

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