Author(s)

Søren Ballegaard^1*, Natasha Bergmann¹, Benny Karpatschof², Jesper Kristiansen³, Finn Gyntelberg³, Lars Arendt-Nielsen⁴, Per Bech⁵, Åke Hjalmarson⁶, Jens Faber^1,7

¹Department of Endocrinology, Herlev Hospital, Herlev, Denmark.
²Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
³The National Research Centre for the Working Environment, Copenhagen, Denmark.
⁴Center for Sensory-Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
⁵Psychiatric Research Unit, Psychiatric Centre North Zealand, University of Copenhagen, Hillerod, Denmark.
⁶Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
⁷Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark.

Background: Depression and ischemic heart disease (IHD) are associated with persistent stress and autonomic nervous system (ANS) dysfunction. The former can be measured by pressure pain sensitivity (PPS) of the sternum, and the latter by the PPS and systolic blood pressure (SBP) response to a tilt table test (TTT). Beta-blocker treatment reduces the efferent beta-adrenergic ANS function, and thus, the physiological stress response. Objective: To test the effect of beta-blockers on changes in depression score in patients with IHD, as well as the influence on persistent stress and ANS dysfunction. Methods: Three months of non-pharmacological intervention aiming at reducing PPS and depression score in patients with stable IHD. Beta-blocker users (N = 102) were compared with non-users (N = 75), with respect to signs of depression measured by the Major Depressive Inventory questionnaire (MDI), resting PPS, and PPS and SBP response to TTT. Results: MDI score decreased 30% in non-users (p = 0.005) compared to 4% (p > 0.1) among users (between-group p = 0.003; effect size = 0.4). Resting PPS decreased in both the groups. Among most vulnerable patients with MDI ≥ 15, reductions in MDI score and resting PPS score correlated in non-users, only (r = 0.69, p = 0.007). Reduction in resting PPS correlated with an increase in PPS and SBP response to TTT. Conclusions: Stress intervention in patients with IHD was anti-depressive in non-users, only. Similarly, the association between the reduction in depression, reduction in persistent stress, and restoration of ANS dysfunction was only seen in non-users, suggesting a central role of beta-adrenergic receptors in the association between these factors.

Chronic Stress, Depression, Autonomic Nervous System, Systolic Blood Pressure, Pain Sensitivity, Beta-Blockers, Ischemic Heart Disease

Ballegaard, S. , Bergmann, N. , Karpatschof, B. , Kristiansen, J. , Gyntelberg, F. , Arendt-Nielsen, L. , Bech, P. , Hjalmarson, Å. and Faber, J. (2016) Association between Depression, Pressure Pain Sensitivity, Stress and Autonomous Nervous System Function in Stable Ischemic Heart Disease: Impact of Beta-Adrenergic Receptor Blockade. Journal of Behavioral and Brain Science, 6, 317-328. doi: 10.4236/jbbs.2016.68031.