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Indonesian avian influenza H274Y mutant neuraminidase homology models assessment

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DOI: 10.4236/jbpc.2011.23039    4,256 Downloads   7,826 Views Citations


Five models of Indonesian H274Y mutant neuralminidase type 1 (N1) were generated from the template 3CKZ by homology modeling. The template has the best similarity percentage 97% with the model sequence. The models was evaluated to search the best model with DOPE, 3D-profiles and PROCHECK in a good rank. The results show model 3 as a potential model to be used in the simulation with the lowest DOPE score, highest verify-3D score and from Ramachandran plots we inferred that it also shared the 1st rank with model 4 based on the 99.4% of the residues found, without Glycine and Proline, at the most favoured and additionally allowed region of both model structures.

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Herlambang, S. and Saleh, R. (2011) Indonesian avian influenza H274Y mutant neuraminidase homology models assessment. Journal of Biophysical Chemistry, 2, 345-352. doi: 10.4236/jbpc.2011.23039.

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