Author(s)

Maria Del Carmen Garcia Molina Wolgien^1.2, Silvana Aparecida Alves Correa^3,4, Pedro Alexandre Federico Breuel⁵, Afonso Celso Pinto Nazário¹, Gil Facina¹

¹Division of Mastology, Department of Gynecology, Federal University of Sao Paulo, Paulista School of Medicine (UNIFESP-EPM), Sao Paulo, Brazil.
²Division of Mastology, Departament of Gynecology, Municipal Hospital and Maternity School Vila Nova Cachoeirinha, Sao Paulo, Brazil.
³Division of Plastic Surgery, Department of Surgery, Federal University of Sao Paulo, Paulista School of Medicine (UNIFESP-EPM), Sao Paulo, Brazil.
⁴Facvest University Center (UNIFACVEST), Post-Graduation Public Health Division, Lages, Santa Catarina, Brazil.
⁵Department of Teaching and Research, Municipal Hospital and Maternity School Vila Nova Cachoeirinha, Sao Paulo, Brazil.

Renin-Angiotensin System (RAS) is involved with hypertension and other cardiovascular diseases. However, the association of RAS components to cancer still causes suspicion. To try to clarify this, here we aimed to show this association for three important components: Angiotensin Converting Enzyme 1 (ACE1), Angiotensin Type 1 Receptor (AGTR1) and Angiotensin Type 2 Receptor (AGTR2). The first articles show that association of RAS components with cancer dates back to the 70’s. ECA1 and AGTR1 have close association with cancer and ACE1 inhibitors or AGTR1 blockers are candidates to treatment of some tumors. Moreover, the action of AGTR2 is still controversial, but most studies show that the increased expression of AGTR2 can attack the cancer cells. In breast cancer, these components have also been widely studied and many works have shown that the correlation exists. Therefore specific target using these RAS components could be a beneficial, novel therapy to various tumors.

Renin-Angiotensin System, Angiotensin Converting Enzyme, Angiotensin Type 1 Receptor, Angiotensin Type 2 Receptor, Breast Cancer, Cancer

Wolgien, M. , Correa, S. , Breuel, P. , Nazário, A. and Facina, G. (2016) Renin Angiotensin System Components and Cancer: Reports of Association. Journal of Biosciences and Medicines, 4, 65-75. doi: 10.4236/jbm.2016.45007.