Author(s)

Sadaf Naeem¹, Rahila Najam¹, Nausheen Alam^2*, Syed Waseem Akhter³

¹Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
²Department of Pharmacology, Faculty of Pharmacy, Federal Urdu University, Karachi, Pakistan.
³Department of Neurology, Karachi Medical and Dental College, Karachi, Pakistan.

Cognitive decline in Parkinson’s disease (PD) is defined as dementia which affects activities of daily living (ADL) function. Dementia is one of the recognized issues in the treatment of Parkinson’s disease patients (PDP) as it is becoming a major contributor to morbidity. The objective of our study was to evaluate the cognitive decline in Parkinson’s disease patients (PDP) and the influence of cognition on daily living function deterioration in cognitively impaired and cognitively unimpaired PDP. Cognitively impaired PDP (n = 24), and cognitively unimpaired PDP (n = 16) were administered MoCA and MMSE performance based tests for cognitive measurements and Alzheimer’s Disease Cooperative Study Activities of Daily Living Inventory (ADCS-ADL) to determine everyday functioning. The significances of MoCA and MMSE among cognitively impaired PDP and cognitively unimpaired PDP in univariant analysis were P < 0.001 and P < 0.05. In partial correlation, MoCA was strongly related to ADL function as compare to MMSE (r = 0.623, P = 0.001). Cognitively impaired PDP showed significantly lower score on visuo-construction and attention. Among all variables of MoCA domains, attention is strongly associated with instrumental activity daily living (IADL) scores (logistic regression coefficient = 0.672, P = 0.01). These results suggest that dementia affects daily living performances especially the IADL tasks like attention and execution. Therefore, the assessment of complex daily activities particularly IADL is probably useful for the diagnosis of early stage cognitive impairment in PDP. Further MMSE test is less sensitive than MoCA for detecting significant cognitive decline in PDP and impaired attention is an important determinant of ADL functions in cognitively impaired PDP.

Parkinson’s Disease Patients, Activities of Daily Living, Montreal Cognitive Assessment, Mini Mental State Ex Amination, Instrumental Activity of Daily Living

Naeem, S. , Najam, R. , Alam, N. and Akhter, S. (2016) A Brief Clinical Assessment of Cognitive Deficit with Impaired Daily Living Functioning in Parkinson’s Patients with and without Dementia. Advances in Parkinson's Disease, 5, 15-23. doi: 10.4236/apd.2016.52003.