Author(s)

Audrey Bélanger^1,2, Catiúscia Padilha de Oliveira¹, Maxim Maheux^1,2,3, Roxane Pouliot^1,2*

¹Centre LOEX de l’Université Laval, Génie Tissulaire et Régénération, LOEX-Centre de Recherche FRQS du CHU, Québec, QC, Canada.
²Faculté de Pharmacie, Université Laval, Québec, QC, Canada.
³TransBIOTech, Centre de Recherche et de Transfert en Biotechnologies, Lévis, QC, Canada.

Covering the entire human body, the skin is considered to be one of the most important organs, since it is the first line of protection against chemical and biological external agents. Although the skin protects tissues and organs against external aggression, it can still be unbalanced by various skin diseases, such as psoriasis. This non-contagious inflammatory dermatosis is characterized by the occurrence of erythematous lesions of various sizes covered with whitish scales. This scaling of the skin is the result of a rapid renewal of the epidermis, occurring over five to seven days instead of 28 days. Psoriasis vulgaris, or plaque psoriasis, is the most common form of this disease and is therefore commonly referred to by the term “psoriasis”. This work is a review of the literature on plaque psoriasis, aiming at a better comprehension of the pathology at the histological level, but also to understand the genetic and environmental factors associated with this inflammatory dermatosis.

Plaque Psoriasis, Clinical Phenotypes, Comorbidities, Genotype-Phenotype Correlation, Susceptibility Gene

Bélanger, A. , de Oliveira, C. , Maheux, M. and Pouliot, R. (2016) Plaque Psoriasis: Understanding Risk Factors of This Inflammatory Skin Pathology. Journal of Cosmetics, Dermatological Sciences and Applications, 6, 67-80. doi: 10.4236/jcdsa.2016.62009.