Author(s)

Enakshi Guru¹, Sanghamitra Chatterjee²

¹Department of Physics, Camellia Institute of Technology, Kolkata, India.
²Department of Electronics, Camellia Institute of Technology, Kolkata, India.

Simple mathematical model of gene expression has been studied thoroughly in this paper. We assume that protein synthesis and protein decay are deterministic in nature whereas transition from active to inactive state is totally stochastic. The probability distribution function of transcript number is calculated and evidence of binary and graded response has been observed for different reaction rates. Slow and fast kinetics have been studied explicitly. Different rate constants play a significant role in calculating distribution function (PDF) and mean value of TF regulated gene expression. It is seen that rate constants control the variance as well. A small change in the value of the rate constant gives a significant change in average protein value. The randomness of gene expression is reduced with increasing value of one of the rate constants. The main focus of this paper is to observe the effect of rate constants in transcription factor regulated gene expression.

Transcription Factor Regulation, Binary and Graded Response, Rate of Protein Activation, Fast and Slow Kinetics, Probability Distribution Function

Guru, E. and Chatterjee, S. (2014) Effect of Rate Constants in TF Regulated Gene Expression. Open Access Library Journal, 1, 1-10. doi: 10.4236/oalib.1101147.