Author(s)

Ryuta Abe, Tomomi Kinoshita, Akiyo Hineno, Shu-ichi Ikeda^*

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.

Joint pain or arthralgia is a common complaint among girls who have received immunization with the human papillomavirus (HPV) vaccine, but the pathogenesis of this disorder has not been completely understood. We report 2 cases of joint lesions after HPV vaccination. In one case, a 13-year-old patient showed transient arthropathy in the right wrist joint after the first dose of Gardasil^® administered in her left shoulder. In the other case, an 18-year-old patient had migrating joint pain with redness and swelling after the third dose of Cervarix^®. Her serum C-reactive protein and anti-MMP-3 levels were slightly elevated, but no autoantibodies, including rheumatoid factor and anti-CCP antibody, were detected. Although various nonsteroidal anti-inflammatory drugs produced no relief, small doses of both tacrolimus and prednisolone were highly effective for her polyarthritis. The development of reactive joint lesions after HPV vaccination was noteworthy.

Human Papillomavirus Vaccine, Adverse Reaction, Arthritis, Arthralgia, Juvenile Idiopathic Arthritis

Abe, R. , Kinoshita, T. , Hineno, A. and Ikeda, S. (2016) Monoarthropathy or Polyarthritis in Adolescent Japanese Girls Who Received Immunization with the Human Papillomavirus Vaccine. Case Reports in Clinical Medicine, 5, 109-114. doi: 10.4236/crcm.2016.53020.