Author(s)

Rafat M. Mohareb^1*, Sherif M. Sherif¹, Wagnat W. Wardakhan², Amr S. Abouzied²

¹Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
²National Organization for Drug Control & Research, Cairo, Egypt.

Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f. The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3-b]pyridine, thieno[2,3-c]pyrimidine and coumarin derivatives was studied. The anti-tumor evaluation of the newly synthesized compounds against the three human tumor cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that compounds 8a, 8b and 14 exhibit higher inhibitory effects towards the three tumor cell lines than the positive control doxorubicin.

Acetoaceanilide, Thiophene, Anti-Tumor, Docking

Mohareb, R. , Sherif, S. , Wardakhan, W. and Abouzied, A. (2014) New Approaches for the Use of Acetoacetanilide in the Synthesis of Thiophenes and Their Fused Derivatives with Anti-Tumor Activity. Open Access Library Journal, 1, 1-16. doi: 10.4236/oalib.1101089.