Author(s)

Chengkua Huang^1*, Guosheng Su^2*, Wen Wei¹, Wenzhong Lu¹, Yinwen Mai¹, Shuliang Hua¹, Yong Zhao¹, Jili Lu¹

¹The People’s Hospital in Baise Guangxi, Youjiang Ethnic Southwest Hospital Affiliated to Medical School Spine Surgery, Baise, China.
²The Fourth People’s Hospital Clinical Laboratory Nanning Guangxi, Guangxi Medical University Affiliated to Infectious Diseases Hospital of Nanning, Guangxi AIDS Clinical Treatment Center (Nanning), Nanning, China.

Objective: This research aims to explore the clinical curative effect for the treatment peripheral nerve injury growth factor of Mecobalamin combined with nerve. Methods: 150 cases of patients with peripheral nerve injury treated in the hospital in July were selected from 2011 to 2013. Those patients were randomly divided into three groups according to the types of injured nerve and the undergoing treatment order. 50 cases are for each group. Patients in group A were injected with 0.5 mg Mecobalamin by intravenous injection. It lasted for once a day, for 10 days. Later, 0.5 mg Mecobalamin was changed to be taken orally, three times a day, a course of treatment. And a course is 3 to 6 weeks. 50 patients in group B were injected with nerve growth factor for 30 micrograms by intramuscular injection, once a day, a course of treatment. And a course is 3 to 6 weeks. While in group C, 50 patients were treated with Mecobalamin (0.5 mg, intravenous injection, once a day) combined with nerve growth factor (30 mg, intramuscular injection, once a day). A course lasted 3 to 6 weeks. The purpose is to observe the therapeutic effect of two different drugs on patients with peripheral nerve injury. Results: The curative effect of Mecobalamin combined with nerve growth factors for the treatment of peripheral nerve injury in group C is more significant than the single drug treatment in group A and group B. Peripheral nerve injury after sensorimotor function rating evaluation of curative effect made by The British Medical Research Institute of Neurotrauma Society was applied in this research. The comparison of the results of 3 groups after treatment is showed as follows. As to the sensory recovery above level II, the curative effect in C group is generally better than in group A and group B, the approximate chi square test H = 13.6573, P = 0.0011. About motion recovery situation, there is a statistical significance in group A and group C which recovered V level X² = 3.8431, P = 0.0499, while there is no obvious difference in group B (P > 0.05). Conclusion: Some certain curative effect is presented of Mecobalamin combined with nerve growth factor in the treatment of peripheral nerve injury, which has an important clinical significance. Therefore, it is worth taking into application.

Mecobalamin, Nerve Growth Factor, Peripheral Nerve Injury

Huang, C. , Su, G. , Wei, W. , Lu, W. , Mai, Y. , Hua, S. , Zhao, Y. and Lu, J. (2016) A Clinical Study on the Treatment of Peripheral Nerve Injury Growth Factor of Mecobalamin Combined with Nerve. World Journal of Neuroscience, 6, 75-81. doi: 10.4236/wjns.2016.62009.