Author(s)

Yoshio Mizuno^1*, Hiromi Fuchikami¹, Naoko Takeda^1,2, Junichi Yamada³, Yuko Inoue², Hiroshi Seto⁴, Kazuhiko Sato¹

¹Department of Breast Oncology, Tokyo-West Tokushukai Hospital, Tokyo, Japan.
²Inoue Ladies Clinic, Tokyo, Japan.
³Department of Clinical Pathology, Tokyo-West Tokushukai Hospital, Tokyo, Japan.
⁴Seto Hospital, Saitama, Japan.

Background: At the 13th St Gallen International Breast Cancer Conference in 2013, a new definition of luminal A-like and luminal B-like breast cancer was proposed, involving the expression of estrogen receptor (ER), progesterone receptor (PgR), and Ki-67. We examined the rate of concordance between the risk groups using the Oncotype DX recurrence score (RS) and the previous and newly proposed luminal subtypes with the standardized Ki-67 assessment. Method: The relationship between a previously and newly proposed, immunohistochemically defined luminal A and B subtype with the Oncotype DX RS of 41 cases of T1-2 N0-1 M0 (ER positive, HER2 negative) breast cancer was assessed. We first classified the patients into the previously defined luminal A and B subtypes, according to the level of Ki-67 as either “low” (<14%) or “high” (≥14%), as assessed by local pathologists. Next, to consider the necessity for standardizing Ki-67 measurement methods, we re-examined Ki-67 with a central review. By introducing PgR positivity (≥20%), we classified these patients to newly proposed luminal subtypes and compared them with the risk groups stratified by Oncotype DX RS. Results: In the previously proposed luminal subtypes, the concordance rate between luminal A and the low RS category was 76.5% according to local pathologists and 90.1% by central review, whereas the rate between luminal B and the intermediate to high RS category was 46.7% and 45.8%, respectively. In newly proposed luminal subtypes, the concordance rate between luminal A and low RS category was 100% and between the luminal B and intermediate to high RS category was 53.6%. Conclusions: Although this study was based on a retrospective chart review of a small sample size, the newly proposed luminal subtypes including addition of PgR positivity with the standardized Ki-67 assessment appeared to improve the concordance rate especially between luminal A and low RS category.

Breast Cancer, Oncotype DX, Ki-67, Standardized Assessment

Mizuno, Y. , Fuchikami, H. , Takeda, N. , Yamada, J. , Inoue, Y. , Seto, H. and Sato, K. (2016) Comparing Oncotype DX Recurrence Score Categories with Immunohistochemically Defined Luminal Subtypes. Journal of Cancer Therapy, 7, 223-231. doi: 10.4236/jct.2016.73023.