Author(s)

Mohammad-Ali Ghaffari¹, Seyedeh-Arefeh Payami², Seyed-Peyman Payami³, Damoon Ashtary-Larky², Abdolrahim Nikzamir⁴, Ghorban Mohammadzadeh^5*

¹Cellular and Molecular Research Center, Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
²Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapour University of Medical Science, Ahvaz, Iran.
³Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁴Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
⁵Hyperlipidemia Research Center, Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Clinically, determination of insulin resistance is important for diabetic patients. We evaluated the relationship among 20/(fasting C-peptide × fasting plasma glucose), HOMA-IR and QUICKI indices in type 2 diabetic patients. The study included 40 patients with type 2 diabetes. Patients divided into three groups based on their medication: metformin, metformin + glibenclamide and metformin + glitazone. Fasting blood sugar, and lipid profile were measured by enzymatic method, serum insulin, and C-peptide were measured by ELISA method. Insulin resistance was calculated by using of 20/(fasting C-peptide × fasting plasma glucose), HOMA-IR and QUICKI indices. There was no significant relationship between 20/(fasting C-peptide × fasting plasma glucose) index and other parameters in all studied groups except QUICKI in metformin group showed a significant correlation with 20/(fasting C-peptide × fasting plasma glucose) index (r = 0.56 and p = 0.03). There was a significant correlation between HOMA-IR and QUICKI indices in all studied groups. There was no significant relationship between 20/(fasting C-peptide × fasting plasma glucose) index with other clinical parameters. On the other hand, our data strongly suggested a significant correlation between HOMA-IR and QUICKI indices in studied subjects with type 2 diabetes.

Type 2 Diabetes, Insulin Resistance, HOMA-IR, QUICKI, 20/(Fasting C-Peptide × Fasting Plasma Glucose)

Ghaffari, M. , Payami, S. , Payami, S. , Ashtary-Larky, D. , Nikzamir, A. and Mohammadzadeh, G. (2016) Evaluation of Insulin Resistance Indices in Type 2 Diabetic Patients Treated with Different Anti-Diabetic Drugs. Open Journal of Endocrine and Metabolic Diseases, 6, 95-101. doi: 10.4236/ojemd.2016.62013.