Author(s)

Sandra Maria Barbalho^1,2*, Ricardo José Toffano³, Marcelo Dib Bechara¹, Karina Rodrigues Quesada¹, Marie Oshiiwa², Claudemir Gregório Mendes¹, Marcia Rocha Gabaldi¹

¹Department of Biochemistry and Celular Biology, Medical School of Marília, UNIMAR, Marília, Brazil.
²Food and Technology School of Marília (FATEC), Sao Paulo, Brazil.
³Department of the Cardiac Surgery Unit and Hemodynamics, Medical School UNIMAR (Hospital Beneficente UNIMAR), Marília, Brazil.

Type 2 diabetes (DM2) is a syndrome characterized by postprandial hyperglycemia normally due to peripheral resistance to insulin and accounts for approximately 90% of diabetes cases worldwide and it is usually related to dyslipidemia, overweight/obesity and physical inactivity and increase in the risk of cardiovascular disease. This study aimed to compare the metabolic and inflammatory profile of hyperglycemic with non-hyperglycemic subjects in a group of patients undergoing coronary arteriography. Our group of patients showed that 63.16% presented glycaemia above 99 mg/dL (from the hyperglycemic patients, 31 individuals were classified as glucose intolerant and 29 as diabetic). Significant differences were found for glycaemia, LDL-c (Low Density Lipoprotein), and hs-CRP (high sensitivity C reactive protein) levels. Nevertheless it is possible to observe that patients with higher glycaemia showed increased values of Total Cholesterol, Triglycerides, LDL-c, Castelli Index I and II and estimative of LDL-c size particle and decreased HDL-c (High Density Lipoprotein) values. The comparison between hs-CRP levels and biochemical parameters shows significant differences for Body Mass Index, Triglycerides, HDL-c and the estimative of LDL-c particle. Also, the presence of Metabolic Syndrome is more prevalent in patients with high levels of hs-CRP. Diabetes patients have more significant increase in morbidity and mortality than the general population frequently due to further complications associated with the resistance to insulin. It is indispensable to outline the anthropometric and biochemical profile from hyperglycemic patients in order to work on secondary prevention of cardiovascular disease.

Hyperglycemia, C-Reactive Protein, Angiography, Castelli Index, Lipids

Barbalho, S. , Toffano, R. , Bechara, M. , Quesada, K. , Oshiiwa, M. , Mendes, C. and Gabaldi, M. (2016) Association between Hyperglycemia, C-Reactive Protein and Other Risk Factors in Patients at Cardiovascular Risk. Journal of Diabetes Mellitus, 6, 16-24. doi: 10.4236/jdm.2016.61003.