Author(s)

Nada Mohammed Ahmed Ali¹, Fath Elrahman Mahdi Hassan Gameel², Mohieldin Elsayid³, Asaad Mohammed Ahmed Abd Allah Babker^4*

¹University of Medical Science and Technology, Khartoum, Sudan.
²Department of Hematology and Immunohaematology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
³Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
⁴Department of Medical Laboratory Science, Al-Ghad International College for Health Sciences, Al-Madinah Almonawarah, Saudi Arabia.

Cardiovascular disease remains the leading cause of mortality and morbidity despite the identification of major risk factors and risk reduction strategies. Myocardial infarction (MI) is a relevant cardiovascular worldwide event for morbidity and mortality. In most cases, sudden cardiac death is triggered by ischemia-related ventricular tachyarrhythmia and accounts for 50% of deaths from cardiovascular disease in developed countries. This is a descriptive analytical case control study aimed to determine D-dimer, PT and PTT level and among patients with acute myocardial infarction conducted in Sudan cardiac center hospital. Thirty patients after MI and twenty normal controls have been studied. The MI patients also include co-exist disease diabetes and hypertension, they receive different anticoagulants therapy. The result demonstrates a significant increase post MI in the mean level of D-dimer (p = 0.00) whereas none significantly compares to control group. There are no differences between INR (0.393), PTT (0.648) and PT (0.393), parameters between cases and controls. In conclusion, our study reveals higher D-dimer level among patients than the control. In conclusion, serum D-dimer levels appear to be useful for diagnosing MI and may assist in the prediction of mortality among those patients which are presented with acute chest pain or known diagnosed with MI and should be done as indicator for thrombosis risk during therapy in post MI.

Myocardial Infarction, D-Dimer Level, PT, PTT

Ali, N. , Gameel, F. , Elsayid, M. and Babker, A. (2016) Alterations in D-Dimer, Prothrombin Time and Activated Partial Thromboplastin Time as Thrombogenesis Activity Markers in Patients with Acute Myocardial Infarction. Open Journal of Blood Diseases, 6, 1-5. doi: 10.4236/ojbd.2016.61001.