Stage II Pancreatic Cancer: Radical, Palliative Surgery or Stenting? - Surgical Science

SS > Vol.6 No.12, December 2015

Stage II Pancreatic Cancer: Radical, Palliative Surgery or Stenting? ()

HTML XML

Download as PDF (Size: 440KB) PP. 555-561

DOI: 10.4236/ss.2015.612079 3,836 Downloads 4,657 Views Citations

Author(s)

Audrius Šileikis¹, Benediktas Kurlinkus², Marius Kryžauskas¹, Kęstutis Strupas¹

Affiliation(s)

¹Vilnius University Center of Abdominal Surgery, Vilnius, Lithuania.
²Vilnius University Center of Gastroenterology and Hepatology, Vilnius, Lithuania.

ABSTRACT

Background: Pancreatic ductal adenocarcinoma is the fourth most common reason of death among oncological diseases with ever increasing mortality. At the time of diagnosis, patients are usually suitable for three ways of treatment: radical, palliative surgery or stenting. Deciding the best option depends on clinical situation, but is still a matter of debate. Methods: We performed a retrospective research of patients with stage II pancreatic head cancer treated in our clinic between years 2002-2014. Four groups were formed according to the used treatment method: group A: radical surgery with R0 (microscopic tumour clearance) margin; group B: radical surgery with R1 (presence of tumour cells within 1 mm of the resection margin) margin; group C: biliary tract stenting; group D: biliodigestive anastomosis. Clinical data and most importantly the survival of these patients were compared. Results: 200 patients were involved in the final analysis, 82 (41%) of them were IIA and 118 (59%) were IIB. Group A consisted of 113 patients; group B consisted of 28 patients; group C consisted of 33 patients; group D consisted of 26 patients. In patients with IIA stage, group A had the highest survival rate compared with other groups, mean survival was 3.242 versus 1.600; 0.454; 0.652 years. Patients with IIB stage of cancer similarly had longer survival in group A versus other groups, 1.720 versus 0.931; 0.713; 0.957 years. Conclusions: Patients with IIA and IIB stage of pancreatic cancer benefit the most from radical surgery with R0 margin. However, for patients with lymph node involvement (stage IIB) and when achieving R0 margin is hardly possible, neoadjuvant treatment seems promising, but we need further randomized controlled trials to fully confirm its effectiveness.

KEYWORDS

Pancreatic Ductal Adenocarcinoma, Radical Surgery, Palliative Surgery, Biliary Tract Stenting

Share and Cite:

Šileikis, A. , Kurlinkus, B. , Kryžauskas, M. and Strupas, K. (2015) Stage II Pancreatic Cancer: Radical, Palliative Surgery or Stenting?. Surgical Science, 6, 555-561. doi: 10.4236/ss.2015.612079.

Journals Menu

Follow SCIRP

	+1 323-425-8868
	customer@scirp.org
	+86 18163351462(WhatsApp)
	1655362766

	Paper Publishing WeChat

Journals Menu

Home

About SCIRP

Service

Policies