Author(s)

Chunguang Han¹, Hisashi Doi², Junji Kimura³, Yoichi Nakao⁴, Masaaki Suzuki^5*

¹Research Center for Materials Science, Nagoya University, Nagoya, Japan.
²RIKEN Center for Life Science Technologies, Kobe, Japan.
³Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan.
⁴Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
⁵National Center for Geriatrics and Gerontology, Obu City, Japan.

¹¹C-labeled C1-C10 partial structure of kulokekahilide-2 (1) was successfully synthesized based on Pd⁰-mediated rapid C-[¹¹C]methylation using [¹¹C]methyl iodide and pinacol alkenylboronate. The preparation of organoboron intermediate via olefin cross-metathesis is also a crucial procedure for the synthesis of ¹¹C-labeling C1-C10 dihy-droxy acid moiety of 1.

Kulokekahilide-2, Carbon-11, Boron, C-C Coupling, Isotopic Labeling

Han, C. , Doi, H. , Kimura, J. , Nakao, Y. and Suzuki, M. (2014) ¹¹C-Labeling of the C(1)-C(10) Dihydroxy Acid Moiety for the Study on the Synthesis of Kulokekahilide-2 PET Tracer. International Journal of Organic Chemistry, 4, 269-277. doi: 10.4236/ijoc.2014.44029.