Author(s)

Masayuki Yamaguchi^*, Yoko Yamagishi, Nobumichi Nishikawa, Masayuki Sekine, Takehiro Serikawa, Katsunori Kashima, Takayuki Enomoto

Department of Obstetrics and Gynecology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Japan.

Objective: To determine outcomes and prognostic factors for early-stage cervical adenocarcinoma/ adenosquamous carcinomas (AC/ASC) patients who are treated with radical hysterectomy and adjuvant therapy to optimize their treatment. Methods: We retrospectively reviewed the medical records of 26 patients with International Federation of Gynecologists and Obstetricians stage IB-IIB cervical AC/ASC who were treated with radical hysterectomy and adjuvant therapy. Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method and compared using the log-rank test. The prognostic significance of various clinical features was determined by using multivariate analysis with the Cox proportional hazards regression model. Results: Univariate analysis revealed that OS was significantly shorter in patients with lymph node metastasis and lymphovascular space invasion. Similarly, PFS was significantly shorter for patients with lymph node metastasis and parametrial invasion. Furthermore, multivariate analysis showed that lymph node metastasis was the only independent predictor for PFS (hazard ratio: 6.47, 95% confidence interval: 1.33 - 31.44, p = 0.021). However, the use of adjuvant chemoradiotherapy did not have any significant effect on either OS or PFS, regardless of lymph node metastasis. Conclusions: Lymph node metastasis is an independent prognostic factor for poor survival in cervical AC/ASC patients treated with radical hysterectomy and adjuvant therapy. In addition, adjuvant chemoradiotherapy does not improve their survival, regardless of lymph node metastasis, which suggests that novel or personalized adjuvant therapeutic strategies with fewer adverse effects than existing strategies are needed.

Adjuvant Therapy, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Lymph Node Metastasis, Prognostic Factors

Yamaguchi, M. , Yamagishi, Y. , Nishikawa, N. , Sekine, M. , Serikawa, T. , Kashima, K. and Enomoto, T. (2014) Outcomes and Prognostic Factors for Adenocarcinoma/Adenosquamous Carcinomas Treated with Radical Hysterectomy and Adjuvant Therapy. Open Journal of Obstetrics and Gynecology, 4, 909-915. doi: 10.4236/ojog.2014.414128.