Author(s)

Thomas Wolters^1,2*, Michael Weber^3,4, Thomas Neumann³, Hans-Georg Strauß¹, Andreas Luchner⁵, Manfred Seeberger⁶, Christian Mueller⁶, Christoph Liebetrau³, Svetlana Apostolovic⁷, Radmilo Jankovic⁷, Dragic Bankovic⁸, Marina Jovic⁸, Vesselin Mitrovic³, Holger Nef^3,9, Helge Mollmann³, Karl Werdan¹, Christian W. Hamm^3,9, Axel Schlitt^1,10

¹Department of Medicine III, University Clinic Halle (Saale), Halle, Germany.
²Department of Medicine, Clinic Grabs, Grabs, Switzerland.
³Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany.
⁴Department of Medicine II, Clinic Groß-Umstadt, Groß-Umstadt, Germany.
⁵Department of Medicine II, University of Regensburg, Regensburg, Germany.
⁶Department of Cardiology, University of Basel, Basel, Switzerland.
⁷University Cardiology Clinic, Niš, Serbia.
⁸Department of Mathematical Sciences, University of Kragujevac, Kragujevac, Serbia.
⁹Department of Medicine I, University Clinic of Gießen and Marburg, Gießen, Germany.
¹⁰Department of Medicine I, Paracelsus-Harz-Clinic Bad Suderode, Quedlinburg, Germany.

Aims: The value of ECG in the perioperative risk stratification under modern treatment options is uncertain. The main objective of the present analysis was to determine the usefulness of a pre-operative ECG derivation for evaluating the risk of perioperative morbidity and mortality. Methods: We performed a secondary analysis of the prospective, international, multicenter, observational “No-Risk” Study (N-terminal B-type natriuretic peptide [NT-proBNP] for the assessment of the perioperative cardiac risk after major noncardiac surgery) to determine the prognostic value of 12-lead ECG. Inclusion criteria were age >55 years and at least one of the following cardiovascular risk factors: arterial hypertension, diabetes mellitus, dyslipidemia, active smoking, and family history positive for coronary heart disease. The combined primary endpoint included total mortality, acute myocardial infarction (NSTEMI and STEMI), cardiopulmonary resuscitation, heart failure, and asystole or ventricular fibrillation during hospitalization. ECGs from 616 patients enrolled from 2006 to 2009 prior to noncardiac surgery in the No-Risk Study were analyzed. Results: The mean age was 67.6 (±8.1) years; 300 (48.7%) patients were male. Fourteen (2.3%) patients suffered from the combined primary endpoint while in the hospital. In Kaplan-Meier analyses, a pathologic Q wave and QTc > 500 ms were significantly related to the incidence of the primary endpoint (p < 0.001, p = 0.042, respectively), whereas other ECG parameters such as LBBB, RBBB, PQ interval, QRS interval, and others were not related to worse in-hospital outcome. Conclusion: The 12-lead ECG is still an important diagnostic tool for perioperative risk assessment of cardiovascular events in noncardiac surgery in patients at risk.

ECG, Perioperative Risk, Cardiovascular Risk

Wolters, T. , Weber, M. , Neumann, T. , Strauß, H. , Luchner, A. , Seeberger, M. , Mueller, C. , Liebetrau, C. , Apostolovic, S. , Jankovic, R. , Bankovic, D. , Jovic, M. , Mitrovic, V. , Nef, H. , Mollmann, H. , Werdan, K. , Hamm, C. and Schlitt, A. (2014) Pathologic Q Waves and Prolonged QTc Time in Preoperative ECG Are Predictive for Perioperative Cardiovascular Events. World Journal of Cardiovascular Diseases, 4, 498-509. doi: 10.4236/wjcd.2014.410060.