Author(s)

Ju Young Lee, Da Yeon Kim, Gyeong Hae Kim, Kkot Nim Kang, Byoung Hyun Min, Bong Lee, Jae Ho Kim, Moon Suk Kim

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The main goal of this work was to develop an optimal self-microemulsifying paclitaxel prepared with PLGA and solubilizer such as tetraglycol, Cremophor ELP, and Labrasol. The prepared PTx-loaded SMES showed the size of the range of 80–130 nm by dy-namic light scattering and a spherical shape by atomic force microscopy. In experiment of storage stability in deionized water (DW) or blood condition, PTx-loaded SMES showed good stability in DW and comparable stability in blood condition at 37^oC for 7 days. In addition, PTx-loaded SMES showed a sig-nificant inhibitory effect on B16F10 melanoma proli-feration. In conclusion, we confirmed that the for-mulations tried in this study could be used as admin-istration form for animal trials of PTx.

Self-Microemulsifying; Paclitaxel; Stability; Anti-Tumor Activity

Lee, J. , Kim, D. , Kim, G. , Kang, K. , Min, B. , Lee, B. , Kim, J. and Kim, M. (2011) Enhanced stability of nano-emulsified paclitaxel. Journal of Biomedical Science and Engineering, 4, 352-356. doi: 10.4236/jbise.2011.45044.