Pyogenic granuloma is a rapidly growing hyperplastic, vascular proliferation of the skin or mucous membrane. A benign lesion of unknown aetiology commonly associated with pregnancy, oral contraceptives and trauma. While lesions occur frequently in oral cavity, occurrence in the nasal septum is rarely reported. We report a case of 38-year-old male (known case of active pulmonary tuberculosis on anti-tubercular therapy) who presented with unilateral pyogenic granuloma of the anterior nasal septum with unilateral nasal obstruction. We emphasize that the rarely seen lobular capillary hemangioma (pyogenic granuloma) must be kept in mind in the differential diagnosis of a rapidly growing mass of the nasal cavity, even without history of epistaxis. Here we report an uncommon case and review current literature regarding aetiology, site and role of rifampicin in pyogenic granuloma.