The object of this paper is to present a new generalization of the Hermite matrix polynomials by means of the hypergeometric matrix function. An integral representation, differential recurrence relation and some other properties of these generalized forms are established here. Moreover, some new properties of the Hermite and Chebyshev matrix polynomials are obtained. In particular, the two-variable and two-index Chebyshev matrix polynomials of two matrices are presented.