Author(s)

Irina Nakashidze, Anzor Diasamidze, Davit Baratashvili, Marina Nagervadze, Manana Alibegashvili, Liana Ramishvili, Manana Gordeziani, Ana Khazaradze, Nanuli Kotrikadze

Department of Biology, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.
Department of Biology, Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia.

Objectives: The aim of the investigation was to study the hormonal status (sex hormones: estradiol (E₂), progesterone (P), testosterone (T); non-sex gonadotropic hormones-luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) of women with benign and malignant tumors of uterine body in the reproductive, menopause and postmenopause periods. Also the distribution features of the blood ABO system phenotype groups and their link to the development of uterine body tumors have been studied. Methods: The determination of hormones was made by the enzyme analysis method (ELAIZA), provided by the proper ELAIZA kits. For the study of blood ABO system antigens, internationally recognized immunoserology methods were used. Results: Investigations revealed the increased level of E₂ and T on the background of the reduced P in the blood of the women with uterine tumors in the reproductive, menopause and post-menopause period. As for gonadotropic hormones, the decreased levels of LH and FSH have also been detected. From the ABO system phenotype groups A(II) group had the highest frequency between the women with malignant uterine tumor in the reproductive age. O (I) phenotype group was the most frequent in case of menopause and post-menopause women with uterine malignant tumors. Conclusions: Hormonal imbalance creates good conditions for the proliferation of uterine tissues and hence causes the development of benign and malignant uterine tumors. The imbalance of the sex steroid and gonadotropic hormones in the blood of post-menopause women indicates on the genotoxic mechanism of cancer development on the background of age-related changes. A(II) group had the highest frequency between the reproductive age women with uterine malignant tumor, while O (I) group was the most frequent in case of menopause and post-menopause patients.

Uterine Body Tumors, Hormones, Benign Tumor, Malignant Tumor, Blood ABO System

Nakashidze, I. , Diasamidze, A. , Baratashvili, D. , Nagervadze, M. , Alibegashvili, M. , Ramishvili, L. , Gordeziani, M. , Khazaradze, A. and Kotrikadze, N. (2014) Alteration of Sex and Non-Sex Hormones and Distribution Features of Blood ABO System Groups among the Women with Uterine Body Tumors. Journal of Cancer Therapy, 5, 411-419. doi: 10.4236/jct.2014.55047.