Author(s)

Jessie Y. W. Chan, David K. K. Tsui, Polly Tsui, Tang Chung Ngai

Department of Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.
Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.

Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPC) is a rare variant of conventional papillary thyroid carcinoma which was first reported in 1985. It appears to be more aggressive than conventional type of papillary thyroid carcinoma. We present a case in a 14-year-old girl who initially presented with thyrotoxicosis and was later diagnosed with DSVPC on subsequent ultrasound and fine need leaspiration when cervicallymph node was evident on clinical examination. Concomitant thyrotoxicosis in thyroid carcinoma is uncommon. The prevalence, clinical presentation, characteristic radiological and histological features, management and prognosis of DSVPC are discussed with literature review. We also hope to illustrate through this case that ultrasound as a non-invasive imaging modality is an invaluable tool for workup in functional thyroid problems and concomitant malignancy may not be that uncommon, so that we could provide prompt treatment to our patients.

Papillary Thyroid Carcinoma; Diffuse Sclerosing Variant; Thyrotoxicosis; Microcalcifications; Ultrasound

Chan, J. , Tsui, D. , Tsui, P. and Ngai, T. (2014) Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma with Concomitant Thyrotoxicosis: A Case Report and Literature Review. Surgical Science, 5, 117-121. doi: 10.4236/ss.2014.53021.