Application of tissue engineering in stem cell therapy - Journal of Biomedical Science and Engineering

JBiSE > Vol.7 No.2, February 2014

Application of tissue engineering in stem cell therapy ()

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Download as PDF (Size: 214KB) PP. 67-74

DOI: 10.4236/jbise.2014.72010 6,450 Downloads 10,022 Views Citations

Author(s)

Jong Kyu Hong, Sang Mo Kwon

Affiliation(s)

Laboratory for Vascular Medicine and Stem Cell Biology, Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea.

ABSTRACT

Tissue engineering based on stem cells has gained interest recently as attempts are made to engineer scaffold environments mimicking the stem cell niche, which contains a reservoir of multipotent stem cells that can maintain normal tissue or restore unhealthy cell populations in response to mechanisms of quiescence, self-renewal, and differentiation of the stem cells. These cell behaviors are governed by soluble signals that are systemic or presented by local niche cells. In this review, current and emergent approaches based on stem cells in the field of tissue engineering are presented for specific applications of human tissues and organs. The combination of stem cells and tissue engineering opens new perspectives in tissue regeneration for stem cell therapy because of the potential to control stem cell behavior with the physical and chemical characteristics of the engineered scaffold environment.

KEYWORDS

Stem Cell; Cell Behavior; Scaffold; Tissue Engineering; Tissue Regeneration

Share and Cite:

Hong, J. and Kwon, S. (2014) Application of tissue engineering in stem cell therapy. Journal of Biomedical Science and Engineering, 7, 67-74. doi: 10.4236/jbise.2014.72010.

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