Author(s)

Tu Kien T. Le, Osamu Hirose, Vu Anh Tran, Thammakorn Saethang, Lan Anh T. Nguyen, Xuan Tho Dang, Duc Luu Ngo, Mamoru Kubo, Yoichi Yamada, Kenji Satou

Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan.
Institute of Science and Engineering, Kanazawa University, Kanazawa, Japan.

Detailed knowledge of interfacial region between interacting proteins is not only helpful in annotating function for proteins, but also very important for structure-based drug design and disease treatment. However, this is one of the most difficult tasks and current methods are constrained by some factors. In this study, we developed a new method to predict residue-residue contacts of two interacting protein domains by integrating information about evolutionary couplings andamino acid pairwise contact potentials, as well as domain-domain interaction interfaces. The experimental results showed that our proposed method outperformed the previous method with the same datasets. Moreover, the method promises an improvement in the source of template-based protein docking.

Residue-Residue Contacts;Domain-Domain Interactions; Protein-Protein Interactions; Domain Interfaces; Residue Co-Evolution; Contact Potentials

Kien T. Le, T. , Hirose, O. , Tran, V. , Saethang, T. , T. Nguyen, L. , Dang, X. , Ngo, D. , Kubo, M. , Yamada, Y. and Satou, K. (2014) Predicting residue contacts for protein-protein interactions by integration of multiple information. Journal of Biomedical Science and Engineering, 7, 28-37. doi: 10.4236/jbise.2014.71005.