Facing problems with oil production decreasing quickly and water content increasing gradually in S103 well area, the Foam Profile Control was studied on the basis of its confirmed agent formula. The facies-controlled geological model of S103 well area was generated using random model based on Petrel software and using numerical simulation based on CMG software. Gas liquid alternating injection pattern was optimized as the optimal solution through the simulation optimization. Two months are optimized as the optimal solution through the simulation optimization. The cumulative oil production is 0.933 × 10⁷ kg which is higher than the value of subsequent water flooding and the other three. Finally, it reaches the goals of slowing down the production decline and controlling the water rising.