Author(s)

Keshava Navin Kumar Reddy, Murugulla Adharvana Chari, Mayur D. Khunt, V. V. N. K. V. Prasada Raju, Bojja Ramachandra Reddy, Vurimidi Himabindu, Ghanta Mahesh Reddy

Department of Chemistry, Institute of Science and Technology, J. N. T. University, Kukatpally, Hyderabad, India.
Dr. MACS Bio-Pharma Pvt. Ltd., Western Hills, Kukatpally, Hyderabad, India.
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy’s Laboratories Ltd., Bachupally, Quthubullapur, India.

This process describes a novel technique for effective trapping of “Pd” metal through resins during the process development of L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy] ethyl ester, and mono hydrochloride known as a Valacyclovir hydrochloride (1). This technique is suitable for large-scale production of 1 and it is described here Pd metal trapping by using different resins.

 

Valacyclovir Hydrochloride; Antiviral Drug; N-Phthalimide-L-Valine Ester; Monomethylamine; Commercially Scalable Process; Less Cycle Time

K. Reddy, M. Chari, M. Khunt, V. Raju, B. Reddy, V. Himabindu and G. Reddy, "New Method of Palladium Metal Trapping through Resins in Antiviral Drug: Valacyclovir HCl," International Journal of Organic Chemistry, Vol. 3 No. 4, 2013, pp. 251-255. doi: 10.4236/ijoc.2013.34036.