Author(s)

Murugulla Adharvana Chari,   Zaied-A-Mosaa, Donthabakthuni Shobha, Sridhar Malayalama

Dr. MACS Bio-Pharma Pvt. Ltd., Pashamylaram, Patancheru, Hyderabad, India.
Dr. MACS Bio-Pharma Pvt. Ltd., Pashamylaram, Patancheru, Hyderabad, India Center for Chemical Science & Technology, Institute of Science & Technology, Jawaharlal Nehru Technological University, Hyderabad, India College of Science for Women, Babylon University, Babylon, Iraq.

Here we demonstrate the synthesis of multifunctionalised benzimidazoles through the coupling of o-phenylenediamine with aldehydes by using Copper (II) hydroxide as an efficient solid catalyst in methanol at room temperature. The Copper (II) hydroxide solid catalyst gave better yields (80%-99%) in short reaction time (4-8 h). These commercially available cheap catalysts are more active than many reported expensive heterogeneous catalysts. Using the Copper hydroxide fresh catalyst, the yield of product 3a was 98%, while the recovered catalyst in the three subsequent cycles gave the yield of 94%, 90% and 88% respectively.

 

o-Phenylenediamine; Aldehydes; Copper (II) Hydroxide; Solid Catalyst; Multifunctionalised Benzimidazoles

M. Chari,  . Zaied-A-Mosaa, D. Shobha and S. Malayalama, "Synthesis of Multifunctionalised 2-Substituted Benzimidazoles Using Copper (II) Hydroxide as Efficient Solid Catalyst," International Journal of Organic Chemistry, Vol. 3 No. 4, 2013, pp. 243-250. doi: 10.4236/ijoc.2013.34035.