Author(s)

Amr Amin, Hatem Nasr, Gehan Younis, Hatem Gamal

Intensive Care Unit, Faculty of Medicine, Cairo University, Cairo, Egypt.
Nuclear Medicine Unit, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Sound prognostic data in sepsis induced acute renal failure (SARF) are lacking especially on the short term outcome [STO] in the intensive care unit [ICU]. We addressed the use of Tc-99m DMSA [2,3-dimercaptosuccinicacid] renal cortical imaging as a prognostic tool in SARF. Methods: Forty patients with acute renal failure due to sepsis [age range 15-74 years; median 44.5] were subjected for full history taking complete physical examination, routine ICU monitoring, routine laboratory investigations, APACHE II [Acute Physiology and Chronic Health Evaluation] and SOFA [Sequential Organ Failure Assessment] together with Tc-99m DMSA cortical renal scintigraphy. Patients’ death in the ICU or discharge was considered as the end point of the study representing the so-called short term outcome [STO]. Results: 25% mortality rate [10/40] was found along the admission period in the ICU. All non-survivors were abnormal with DMSA imaging [NPV & PPV 100% & 66.7% respectively]. Abnormal DMSA cases showed significant positive associations with serum creatinine at admission [r = 0.5; P 0.02]; admission duration [r = 0.4; P 0.002]; APACHE II score [r = 0.5; P 0.004] and STO [r = 0.4; P 0.03]. Statistically significant difference was elicited between subjects with normal and abnormal DMSA regarding the same parameters. Conclusion: This preliminary data could raise Tc-99m DMSA renal imaging as a prognostic tool in SARF that could allow influential interference to prohibit dramatic outcomes as mortality.

Acute Renal Failure; Tc-99m DMSA; Sepsis Induced Acute Renal Failure

A. Amin, H. Nasr, G. Younis and H. Gamal, "Short Term Prognostic Utility of Tc-99m DMSA Renal Imaging in Sepsis Induced Acute Renal Failure; Provisional Data," International Journal of Clinical Medicine, Vol. 4 No. 12, 2013, pp. 543-547. doi: 10.4236/ijcm.2013.412094.