This paper discusses the discovery and study of the functional connection between the quark masses and their mixing parameters. That allowed calculating Cabibbo angle from the known values of the masses of two lower quarks. It has been established that mixing occurs not only among lower quarks, as it was known up to now, but the upper quarks, independently, do the same. A separate mixing angle is calculated for the latter. The existence of “two Cabibbo angles”, i.e. independent mixings of upper and lower quarks, is a strong argument in favor of models with not one, but with several Higgs bosons. Only taking into account such a link, it is possible to give the unified description of the dependence of the mass on the generation number for all charged fermions (except t-quark). It turns out that increments of values and N are linearly linked. (Here m and N—mass and generation number of fermion, A—common internal parameter of concerned fermions).