The Himalaya is a region sensitive to climate change. Changes in the glacial regime are one indicator of global climate changes. There are several studies focusing on analysis of temporal changes of these glacial lakes in the Himalaya region. However, the researches on addressing these trends in relation with surrounding topographical conditions are quite limited. In this study, we analyzed spatio-temporal changes in Imja Lake, located on the southern slope, and Karda Lake, located on the northern slope of the Mt. Everest region, in 1976, 1992, 2000, and 2008. Moreover, we examined whether the topographic conditions differ between the two slopes. Landsat and ASTER GDEM (advanced space borne thermal emission and reflection radiometer, global digital elevation model) data were used to identify boundaries of target glacial lakes and to calculate three indices of growth rate compared to year of 1976 (%, GR_a), growth rate compared to preceding year (%, GR_b), and growth speed (m²/year, GS) of the two lakes. The topographic conditions in circular buffer zones from the centroid of the two lakes were analyzed. Although the area of two lakes demonstrated linear increase from 1976 to 2008, growth rate compared to year of 1976 (GR_a) differed significantly (Kruskal-Wallis test, p < 0.05). The area of Imja Lake enlarged significantly faster than the one of Karda Lake (Kruskal-Wallis test and Chisquared test for independence on m × n contingency table between 1976, 1992, 2000, and 2008 on growth speed (GS)). The two slopes differed in terms of three topographical variables: altitude, aspect, and angle of inclination (Kruskal-Wallis test, p < 0.05). The differences between the growth trends of the two lakes can be explained by differences in the topographic conditions on their respective slopes. However, differences in temporal changes should be explained by other temporal factors, e.g. climatic variables.