Identification and preliminary characterization of novel B3-type metallo-β-lactamases - American Journal of Molecular Biology

AJMB > Vol.3 No.4, October 2013

Identification and preliminary characterization of novel B3-type metallo-β-lactamases ()

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DOI: 10.4236/ajmb.2013.34026 3,203 Downloads 6,305 Views Citations

Author(s)

Manfredi Miraula, Conor S. Brunton, Gerhard Schenk, Nataša Mitić

Affiliation(s)

Department of Chemistry, National University of Ireland—Maynooth, Maynooth, Co., Kildare, Ireland.
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.

ABSTRACT

Antibiotic resistance has emerged as a major global threat to human health. Among the strategies employed by pathogens to acquire resistance the use of metallo-β-lactamases (MBLs), a family of dinuclear metalloenzymes, is among the most potent. MBLs are subdivided into three groups (i.e. B1, B2 and B3) with most of the virulence factors belonging to the B1 group. The recent discovery of AIM-1, a B3-type MBL, however, has illustrated the potential health threat of this group of MBLs. Here, we employed a bioinformatics approach to identify and characterize novel B3-type MBLs from Novosphingobium pentaromativorans and Simiduia agarivorans. These enzymes may not yet pose a direct risk to human health, but their structures and function may provide important insight into the design and synthesis of a still elusive universal MBL inhibitor.

KEYWORDS

Antibiotic Resistance; β-Lactam Antibiotics; Metallo-β-Lactamases; Sequence Homology; Novosphingobium Pentaromativorans; Simiduia Agarivorans

Share and Cite:

Miraula, M. , Brunton, C. , Schenk, G. and Mitić, N. (2013) Identification and preliminary characterization of novel B3-type metallo-β-lactamases. American Journal of Molecular Biology, 3, 198-203. doi: 10.4236/ajmb.2013.34026.

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