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Roles of antigen receptors and CA215 in the innate immunity of cancer cells

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DOI: 10.4236/oji.2013.33018    3,139 Downloads   5,873 Views Citations
Author(s)
Gregory Lee, Suefay Liu

Affiliation(s)

UBC Center for Reproductive Health, University of British Columbia, Vancouver, Canada.

ABSTRACT

Antigen receptors, including immunoglobulins and T-cell receptors, are known to be widely expressed by cancer cells through unconfirmed mechanisms and for unknown purposes. Recently, a monoclonal antibody, designated as RP215, was generated against the ovarian cancer cell line, OC-3-VGH, and was shown to react with CA215, which consisted mainly of these cancer cell-expressed antigen receptors. Experimental evidence has clearly indicated that cancerous immunoglobulins play significant roles in the growth and proliferation of cancer cells in vitro and in vivo. RP215 and anti-antigen receptor antibodies were equally effective in inducing apoptosis and complement-dependent cytotoxicity reactions to cultured cancer cells. Through gene regulation studies, both RP215 and antibodies against antigen-receptors were shown to affect more than a dozen of genes involved in cell proliferation (such as NFκB-1, IgG, P21, cyclin D1, ribosomal P1, and c-fos). Furthermore, selected toll-like receptor genes (TLR- 2, -3, -4, and -9) were also found to be highly regulated by both RP215 and anti-antigen receptor antibodies. For example, RP215 and anti-antigen receptor antibodies were found to both up-regulate TLR-2 and/or TLR-3 and down- regulate TLR-4 and TLR-9 intwo types of cancer cells. Based on these studies, it is reasonable to postulate that cancerous immunoglobulins play important roles in the modulation of the innate immune system to allow the growth and survival of cancer cells within the human body. Consequently, RP215 inits humanized forms may be utilized to target cancer cells for potential therapeutic purposes.

KEYWORDS

Antigen Receptors; CA215; Cancer Immunity; Immunoglobulins; Innate Immunity; RP215; T Cell Receptors; Toll-Like Receptors

Cite this paper

Lee, G. and Liu, S. (2013) Roles of antigen receptors and CA215 in the innate immunity of cancer cells. Open Journal of Immunology, 3, 127-138. doi: 10.4236/oji.2013.33018.
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