Convenient Cleavage Reaction of 1-Acylhydantoin to Amide - International Journal of Organic Chemistry

IJOC > Vol.3 No.3, September 2013

Convenient Cleavage Reaction of 1-Acylhydantoin to Amide ()

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Download as PDF (Size: 171KB) PP. 194-197

DOI: 10.4236/ijoc.2013.33025 4,607 Downloads 7,123 Views Citations

Author(s)

Jun-ichi Yamaguchi, Kanako Nozaki Abe, Takao Narushima

Affiliation(s)

Department of Applied Chemistry, Kanagawa Institute of Technology, Kanagawa, Japan.

ABSTRACT

A cleavage reaction of 1-acylhydantoin by an amine in tetrahydrofuran at elevated temperature provided the corre-sponding amide and hydantoin in high yield. It was found that the addition of diethylaluminum chloride accelerated the cleavage reaction rate. The amide yield depended on the steric hindrance of the amine.

KEYWORDS

Amides; Acylhydantoin; Chiral Auxiliaries; Cleavage; Lewis Acid

Share and Cite:

J. Yamaguchi, K. Abe and T. Narushima, "Convenient Cleavage Reaction of 1-Acylhydantoin to Amide," International Journal of Organic Chemistry, Vol. 3 No. 3, 2013, pp. 194-197. doi: 10.4236/ijoc.2013.33025.

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