Author(s)

Shoko Horita, Motonobu Nakamura, Masashi Suzuki, Hideomi Yamada, George Seki

Department of Internal Medicine, The University of Tokyo Hospital, Tokyo, Japan.

Insulin resistance, closely linked to inflammation, is recognized as a key factor in the onset and aggravation of diabetes, cardio-renal syndrome, hypertension, and obesity. In the renal proximal tubule, insulin resistance may increase renal sodium reabsorption, leading to hypertension, edema and sometimes heart failure. Recently some anti-diabetic agents have been shown to have effects on the transporters in renal proximal tubule. Because renal proximal tubule mediates about 70% of sodium reabsorption, it is quite important to clarify the function of renal proximal tubule under insulin resistance and inflammation.

Insulin; Inflammation; TNF-α; Proximal Tubule; Insulin Resistance; PPARγ; Thiazolidinediones

S. Horita, M. Nakamura, M. Suzuki, H. Yamada and G. Seki, "The Effects of Insulin Resistance and Inflammation on Renal Proximal Tubule Sodium Transport and Hypertension," Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 5A, 2013, pp. 34-41. doi: 10.4236/ojemd.2013.35A003.