Strategies in secondary biliary fibrosis - Journal of Biomedical Science and Engineering

JBiSE > Vol.6 No.8, August 2013

Strategies in secondary biliary fibrosis ()

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DOI: 10.4236/jbise.2013.68A2002 4,628 Downloads 6,681 Views Citations

Author(s)

José M. Hermosillo-Sandoval, Adolfo D. Rodríguez-Carrizález, Alejandra G. Miranda-Díaz

Affiliation(s)

Department of Surgery, Specialties Hospital of the National Occidental Medical Centre, Social Security Institute of Mexico, Guadalajara, México.
University Health Sciences Centre, University of Guadalajara, Guadalajara, México.

ABSTRACT

The cellular and molecular mechanisms that mediate hepatic fibrosis have provided a framework of different therapeutic foci to prevent, delay or in such case revert fibrosis and cirrhosis. The fundamental event in development of hepatic fibrosis caused by secondary biliary cholestasis is based on activation of the hepatic stellar cells (HSC) which the primary function is forming fibrosis. The activated HSC cells transform into myofibroblasts with capacity to produce alpha smooth muscle actin (α-SMA). As a result, the HSC activates proliferation of the cholangiocytes and epithelial cells whose functions represent important anti-fibrotic objectives. Some strategies are described as targeting against molecule involved in fibrosis production; and some medications with anti-fibrotic functions that are actually available in the medical arsenal have been tested in experimental animal models and in few clinical studies, and their components act in relation to the fibrotic cascade. In the end, the treatment strategies for hepatic fibrosis can vary on an individual basis depending on the etiology, the risk of fibrosis progression and the predominant pathogenic medium, which indicates that a multi-factorial approach could be necessary. Orthotopic liver transplant continues being the last final alternative for hepatic insufficiency from any cause; however, in no way does it supersede healthy natural liver in survival and adequate function. The investigative arsenal continues to develop rapidly, giving rise to other possible objectives in pre-clinical studies of conceptual trials, such as the utilization of molecular, cellular, drugs therapy and Chinese herbs. Despite being aforementioned, there are no existing ideal alternatives that completely reverse fibrosis in humans. Future usefulness of the majority of management alternatives seems probable and could be feasible.

KEYWORDS

Bile Duct Lesion; Bile Duct Injury; Bile Duct Atresia; Hepatic Cholestasis; Secondary Biliary Fibrosis; Hepatic Transplant

Share and Cite:

Hermosillo-Sandoval, J. , Rodríguez-Carrizález, A. and Miranda-Díaz, A. (2013) Strategies in secondary biliary fibrosis. Journal of Biomedical Science and Engineering, 6, 10-18. doi: 10.4236/jbise.2013.68A2002.

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