Author(s)

Emma Arakelova, Ashot Khachatryan, Karapet Avjyan, Zoya Farmazyan, Alvard Mirzoyan, Lilia Savchenko, Sedrak Ghazaryan, Flora Arsenyan

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Zinc oxide nanocomposites in the form of coatings and composite films with antitumor activity were obtained by deposition of ZnO nanofilms on surfaces of ethyl ether Sali- cylidene DL-tyrosine (S1) and ethyl ether Sali- cylidene DL-tyrosine Cu (II) chelate (S2) by magnetron sputtering of Zn target. Ethyl ether salicylidene DL-tyrosine, Cu (II) chelate of ethyl ether salicylidene DL-tyrosine reveal some anticancer properties. Their zinc oxide nano- composites were obtained in the form of coat- ings (S1 + ZnO, S2 + ZnO) and composite films presenting a mixture of polyvinyl alcohol (PVA) with S1, S2 (S1 + PVA + ZnO, S2 + PVA + ZnO), for the purpose of increasing anticancer activity. Considerable increase in antitumor activity re- veal ZnO nanocomposites with salicylidene amino acid chelates (as distinct from their ethers) in the form of S2 + ZnO (47%) and S2 + PVA + ZnO (48%) in comparison with S2 (20%). Structural, spectral properties of the salicylidene amino acids and their ZnO nanocomposites were studied.

Zinc Oxide; Nanofilm; Magnetron Sputtering; Nanocomposites;Antitumor Activity

Arakelova, E. , Khachatryan, A. , Avjyan, K. , Farmazyan, Z. , Mirzoyan, A. , Savchenko, L. , Ghazaryan, S. and Arsenyan, F. (2010) Zinc oxide nanocomposites with antitumor activity. Natural Science, 2, 1341-1348. doi: 10.4236/ns.2010.212163.