Author(s)

T. S. Balmukhanov, A. K. Khanseitova, V. G. Nigmatova, S. P. Varchenko, Sh. Zh. Talaeva, N. A. Aitkhozhina

Structural and Functional Genomics Laboratory, Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.

Associations of polymorphisms in rs4646903 site of CYP1A1 and rs1056836 site of CYP1B1 genes with the breast cancer (BC) were studied in two main ethnic groups of Kazakhstan Republic (Kazakhs and Russians). Total number of BC patients was 181, controls—397. The statistically significant differences were revealed in allele frequencies (χ² = 5.93, р = 0.004) and in genotypes distribution (χ² = 8.71, р = 0.015) in rs4646903 site of CYP1A1 gene in Kazakh but not in Russian group. The study of CYP1В1 rs1056836 site demonstrated differences in genotype distributions (χ² = 7.48, р = 0.023) between BC patients and controls in Russian but not in Kazakh ethnic group.

Breast Cancer; Gene Polymorphism; CYP1A1; CYP1B1; Kazakhstan

Balmukhanov, T. , Khanseitova, A. , Nigmatova, V. , Varchenko, S. , Talaeva, S. and Aitkhozhina, N. (2013) Associations of Polymorphisms of the CYP1A1 and CYP1B1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan. Advances in Breast Cancer Research, 2, 51-55. doi: 10.4236/abcr.2013.23009.