Author(s)

Margarita Kruchinina, Mikhail Voevoda, Sergey Peltek, Svetlana Kurilovich, Abdrey Gromov, Vladimir Kruchinin, Sergey Rykhlitsky, Vladimir Volodin, Vladimir Generalov

Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia.
Institute of Internal Medicine, SB RAMS, Novosibirsk, Russia.
Rzhanov Institute of Semiconductor Physics, SB RAS, Novosibirsk, Russia.
State Research Center of Virology and Biotechnology, Ministry of Public Health and Social Development of the Russian Federation, Koltsovo, Russia.

Possible early diagnostic application of optical methods (dielectrophoresis, spectral and imaging ellipsometry, Fourier-transform infrared spectroscopy, Raman spectroscopy) in studies of red blood cells and serum of patients with diffuse liver disease with varying degrees of fibrosis has been evaluated. Application of combined optical methods was confirmed to significantly improve the performance of sensitivity, specificity, and accuracy index as well as to achieve the reliable results in diagnosis of both severe fibrosis and slight ulterior liver fibrosis. Identified diagnostic potential of optical methods can be effectively utilized in noninvasive screening evaluation of stages of diffuse liver disease of various geneses.

Optical Methods; Blood Serum Studies; Erythrocytes; Diffuse Liver Disease; Degree of Fibrosis; Dielectrophoresis; Ellipsometry; Raman Spectroscopy; IR Fourier Spectroscopy

M. Kruchinina, M. Voevoda, S. Peltek, S. Kurilovich, A. Gromov, V. Kruchinin, S. Rykhlitsky, V. Volodin and V. Generalov, "Application of Optical Methods in Blood Studies upon Evaluation of Severity Rate of Diffuse Liver Pathology," Journal of Analytical Sciences, Methods and Instrumentation, Vol. 3 No. 2, 2013, pp. 115-123. doi: 10.4236/jasmi.2013.32014.