Background: Eosinophilic esophagitis (EoE) is thought to be more common in males and Caucasians, yet little data exists regarding the presentation of EoE among children. Methods: A retrospective study of children undergoing esophagogastroduodenoscopy (EGD) was done to determine gender and racial differences in the prevalence and presenting symptoms of EoE. Data collected included gender, race, indication for EGD, and presence of EoE. Results: No gender or racial differences were found for indication for EGD. EoE was identified in 4.1% of children, more commonly in males than females (6% vs. 2.5%, p < 0.01). No racial difference was seen. Symptoms showing a racial/gender difference included dysphagia, vomiting, and foreign body impaction. Conclusions: Prevalence of EoE differs by gender, but not race. Gender/racial differences exist for EoE in children presenting with dysphagia, vomiting, and foreign body impaction. This data may help guide the clinician on when to refer for EGD.