Author(s)

Jun Li, Shoufang Jiang, Yongli Chang, Zhong Guo, Sanqiao Yao, Juxiang Yuan, Guoli Li

Center for Disease Control and Prevention in Tangshan City, Tangshan, China.
Center for Disease Control and Prevention in Yutian County, Tangshan, China.
Medical College, Hubei Arts and Sciences University, Xiangyang, China.
School of Public Health, Hebei Union University, Tangshan, China.
Xingtai Medical Higher Junior College, Xingtai, China.

Background: The purpose of this study was to evaluate the association among serum organochlorine pesticide residues, glutathione S-transferase M1 genetic polymorphism and female breast cancer. Methods: A 1:1 matched case-control study of 140 newly diagnosed breast cancer patients and 140 non-cancer female patients who consulted the five largest hospitals in the Tangshan city from September 2006 to October 2007. Results: The result showed higher risk of breast cancer among subjects with higher levels of serum DDT and HCH residue, the OR was 3.18 (95%CI, 1.11 - 9.07) and 5.02 (95%CI, 1.64 - 16.56).The value of OR_e associated with single environmental factor DDT high residues_, and OR_g associated with single GSTM1 deletion genotype were respectively 3.86 (1.20 - 12.47) and 1.34 (0.36 - 5.08). The OR_eg associated with combined action of two factors was 5.59 (1.63 - 18.90), and the value of interaction parameters (γ) equaled 1.24. The value of OR_e associated with single environmental factor HCH higher residue and OR_g associated with single GSTM1 deletion genotype were respectively 2.73 (0.84 - 8.87) and 1.48 (0.49 - 4.60). The value of OR_eg associated with combined action of two factors was 3.87 (1.18 - 12.68), and γ equaled 1.38. Conclusion: The results indicated that breast cancer occurrence was the combined result of environmental and genetic factors. The concurrent action of GSTM1 deletion genotype and DDT/HCH enhanced the risk of breast cancer.

Breast Cancer; DDT; HCH; Glutathione S-Transferase M1 (GSTM1); Endocrine Disruptors; Gene Polymorphism; Interaction

Li, J. , Jiang, S. , Chang, Y. , Guo, Z. , Yao, S. , Yuan, J. and Li, G. (2013) Association among Serum Organochlorine Pesticide Residues, Glutathione S-Transferase M1 Genetic Polymorphism and Female Breast Cancer. Advances in Breast Cancer Research, 2, 19-23. doi: 10.4236/abcr.2013.22005.