This study explores the influence that familial socioeconomic status, school life adjustment, and deviant behavior have on the well-being of junior high school students. The participants were 1886 first-year junior high school students recruited using the Taiwan Education Panel Survey (TEPS). The findings of this study indicated that a) the well-being of male students exceeded that of female students; b) significant interaction effects were exhibited between familial socioeconomic status and school life adjustment, and higher familial socioeconomic status and higher school life adjustment with higher well-being; and c) deviant behavior was related to lower well-being.