Considering the characteristics of spatial straightness error, this paper puts forward a kind of evaluation method of spatial straightness error using Geometric Approximation Searching Algorithm (GASA). According to the minimum condition principle of form error evaluation, the mathematic model and optimization objective of the GASA are given. The algorithm avoids the optimization and linearization, and can be fulfilled in three steps. First construct two parallel quadrates based on the preset two reference points of the spatial line respectively; second construct centerlines by connecting one quadrate each vertices to another quadrate each vertices; after that, calculate the distances between measured points and the constructed centerlines. The minimum zone straightness error is obtained by repeating comparing and reconstructing quadrates. The principle and steps of the algorithm to evaluate spatial straightness error is described in detail, and the mathematical formula and program flowchart are given also. Results show that this algorithm can evaluate spatial straightness error more effectively and exactly.