Epigenetics mechanisms and degenerative diseases - Open Journal of Genetics

OJGen > Vol.2 No.4, December 2012

Epigenetics mechanisms and degenerative diseases ()

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Download as PDF (Size: 213KB) PP. 173-183

DOI: 10.4236/ojgen.2012.24023 5,827 Downloads 9,011 Views Citations

Author(s)

Kalpana Joshi, Smitha Bhat, Pooja Deshpande, Mayura Sule, Kapaettu Satyamoorthy

Affiliation(s)

Manipal Life Sciences Centre, Planetarium Complex, Manipal University, Manipal, India.
School of Biomedical Sciences, Symbiosis International University, Pune, India.
Sinhgad Institute, Pune, India.

ABSTRACT

Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms include histone modifications and DNA methylations. In this review, we examine methods to study DNA methylations and their contribution to degenerative diseases by mediating the complex gene-by-environment interactions. Such epigenetic modifications despite being heritable and stably maintained are also potentially reversible and there is scope for the development of epigenetic therapies for this disease.

KEYWORDS

Epigenetics; DNA Methylation; Histone Modifications; DNA Methylation; Rheumatoid Arthritis

Share and Cite:

Joshi, K. , Bhat, S. , Deshpande, P. , Sule, M. and Satyamoorthy, K. (2012) Epigenetics mechanisms and degenerative diseases. Open Journal of Genetics, 2, 173-183. doi: 10.4236/ojgen.2012.24023.

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